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2 The relationship between intestinal microenvironment and PSCI The intestinal microenvironment is the most complex part of the human microbiota, composed of gut microbiota, intestinal mucosa, and gut immune system, which are strongly associated with various types of diseases in the human body ( In addition to digestion and absorption, normal intestinal function also has a strong barrier function against harmful microbial organisms and various toxins produced by the intestine which is achieved through the intestinal epithelial barrier (IEB)